Introductory notes for the Acta IMEKO Special Issue on the 24th IMEKO Technical Committee 4 International Symposium and the 22nd International Workshop on Analogue-to-Digital Conversion and Digital-to-Analogue Conversion Modelling and Testing

Measurement has always been a tool by which we can observe the world around us. This concept was once again confirmed during the 24th IMEKO Technical Committee 4 (TC4) International Symposium, which showed how topics related to the world of measurement range across many fields of knowledge. The IMEKO TC4 International Symposium is one of the most important events in the fields concerned with the theoretical and practical aspects of the measurement of electrical quantities and related instrumentation. It involves institutions and academia in a discussion of the state of the art and issues that require a joint approach by engineers, academics and other experts of measurement, instrumentation, testing and metrolog

The ubiquitin-proteasome pathway in cancer.

Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance

A Novel Generic Framework for Track Fitting in Complex Detector Systems

This paper presents a novel framework for track fitting which is usable in a wide range of experiments, independent of the specific event topology, detector setup, or magnetic field arrangement. This goal is achieved through a completely modular design. Fitting algorithms are implemented as interchangeable modules. At present, the framework contains a validated Kalman filter. Track parameterizations and the routines required to extrapolate the track parameters and their covariance matrices through the experiment are also implemented as interchangeable modules. Different track parameterizations and extrapolation routines can be used simultaneously for fitting of the same physical track. Representations of detector hits are the third modular ingredient to the framework. The hit dimensionality and orientation of planar tracking detectors are not restricted. Tracking information from detectors which do not measure the passage of particles in a fixed physical detector plane, e.g. drift chambers or TPCs, is used without any simplifications. The concept is implemented in a light-weight C++ library called GENFIT, which is available as free software

Rotor bar pre-fault detection in the squirrel cage induction motors

The paper deals with a diagnosis technique to detect and monitor incipient faults in the rotor bars of squirrel gage induction motors. The failure mode analysis is performed monitoring the motor axial vibrations. To accomplish the task, the authors present a mathematical model that allows relating the occurrence and the severity of the faults to the presence and the magnitude of some frequency components of the axial vibration spectrum. To validate the proposed approach, the results obtained by applying the mathematical model are compared with the ones obtained by experimental tests done on both healthy and faulty motors

Voltage source inverters: an easy approach for fast fault detection

Peer Reviewe

Characterization of the parameters of interior permanent magnet synchronous motors for a loss model algorithm

The paper provides the results of a detailed experimental study on the variations of the characteristics of an interior permanent magnet synchronous motor, when load, speed and/or magnetization conditions vary. In particular, the characterization is carried out by assessing, for several working conditions, the motor parameters that influence its efficiency. From the knowledge of the variability of these parameters, it is possible to develop a dynamic model of the motor, which accurately describes its behaviour and allows estimating the power losses for whatever speed and load. In order to validate the model, the values of the power losses obtained by using the model are compared with the values measured with experimental tests. The study shows that it is possible to maximize the motor efficiency just acting on the direct axis current component and, therefore, it can be considered a first step towards the definition of a loss model algorithm for a control drive system able to minimize in real-time the power losses of the motor

Tourism, natural protected areas and open source geospatial technologies.

The Covid-19 outbreak has greatly impacted society behaviours fostering proximity tourism and valorising the social role of peri-urban natural protected areas as key locations for outdoor activities. FOSS and FOSS4G can play a critical role to support the value creation for these sites. This work evaluates its application in the context of two different protected areas for the creation of 3D digital products, the monitoring of touristic fluxes and the conduction of parks management activities. To this aim three solutions that copes with the mentioned aspects are presented and gaps, weakness and limitations evaluated. The investigated solutions consists in: the data workflow from survey to 3D rendering using Blender and GIS plugin; the touristic fluxes monitoring system based on a machine learning algorithm for image recognition from captured video data streams and istSOS; and finally the park assets management system which is based on PostGIS and OpenLayers

An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts

: In the human body, the skin is one of the organs most affected by the aging process. Nutritional approaches aimed to counteract the age-induced decline of extracellular matrix (ECM) deposition could be a valuable tool to decrease the degenerative processes underlying skin aging. Here, we investigated the ability of a six-amino acid plus hyaluronic acid (6AAH) formulation enriched with tricarboxylic acid (TCA) intermediates to stimulate ECM gene expression. To this aim, human BJ fibroblasts were treated with 6AAH alone or plus succinate or malate alone or succinate plus malate (6AAHSM), and mRNA levels of several ECM markers were evaluated. 6AAHSM increased the expression of all the ECM markers significantly above 6AAH alone or plus only succinate or malate. Furthermore, in an in vitro oxidative damage model, 6AAHSM blunted the hydrogen peroxide-induced decline in ECM gene expression. Our data suggest that feeding cells with 6AAH enriched with TCAs could efficiently be employed as a non-pharmacological approach for counteracting skin aging

Comparison of three control drive systems for interior permanent magnet synchronous motors

In a previous paper, we proposed a control strategy for interior permanent synchronous motors, which takes into account also the reduction of the motor power losses. The novelty of the suggested approach is that it takes into consideration the variations of all the motor parameters that have an influence on its efficiency. In order to verifyon the field the effectiveness of this new method, we implemented the proposed loss model algorithm in a control drive system and compared its performances, in terms of energy losses with respect to other conventional techniques